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Cannabis use appears to encourage, not replace, non-medical opioid use

by EurekAlert!, posted 08 10 2020

A study published in the scientific journal Addiction suggests that, contrary to what some are claiming, people in the US may not be substituting cannabis for opioids.

This study examined the direction and strength of association between cannabis and opioid use over 90 consecutive days. Among adults who used non-medical opioids, the study compared the probability of non-medical opioid use on days when cannabis was used with days when cannabis was not used. The study included 13,271 days of observation among 211 participants from the greater New York area. The participants were predominantly male, urban, unemployed, unmarried, and had a high prevalence of substance misuse and pain. The results showed that opioid use was at least as high on days when cannabis was used as on days when it was not. This was true irrespective of the levels of pain being experienced by participants.

The study was limited by virtue of reliance on self-report of substance use and the fact that it did not determine whether cannabis or opioids were used first on a given day.

Study co-author, Deborah Hasin, states, "Our study is among the first to test opioid substitution directly, suggesting that cannabis seldom serves as a substitute for non-medical opioids among opioid-using adults, even among those who report experiencing moderate or more severe pain. In other words, our study suggests that cannabis is not an effective way to limit non-medical opioid use."

In 2017, there were over 2 million people with opioid use disorder and over 70,000 opioid-related deaths in the US. Illicit opioid use, including non-medical use of prescription opioids, synthetic opioids and heroin, is the primary cause of overdose deaths among US adults. Understanding how cannabis may change non-medical opioid use is critical to informing discussions around cannabis-based interventions for addressing the opioid crisis.


For editors:

Peer reviewed: Yes

Type of study: Longitudinal study

Subject of study: People

Funding: Government/research council

This paper is free to download for one month from the Wiley Online Library: or by contacting Jean O'Reilly, Editorial Manager, Addiction,

To speak with lead author Professor Deborah Hasin: contact her at Columbia University by email ( or

Full citation for article: Gorfinkel L, Stohl M, Greenstein E, Aharonovich E, Olfson M, and Hasin D (2020) Is cannabis being used as a substitute for non-medical opioids by adults with problem substance use in the US?: A within-person analysis. Addiction 115: doi: 10.1111/add.15228

Addiction is a monthly international scientific journal publishing peer-reviewed research reports on alcohol, substances, tobacco, and gambling as well as editorials and other debate pieces. Owned by the Society for the Study of Addiction, it has been in continuous publication since 1884.

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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